Abstract—In this paper, the thermodynamic, environmental and economic analysis is conducted on 210 MW dual fired Jamshoro Power plant unit, operating it on MSW generated in Hyderabad City. Firstly, a mathematical model has been developed for MSW operated Jamshoro Power plant and is analyzed in Engineering Equation Solver (EES) software. The thermodynamic parameters including mass flow rate of MSW required, net power output and energy efficiency are determined. The environmental effects including mass of flue gases is calculated and a comparative study is performed between parameters of existing power plant and modeled MSW plant. The economics of the plants including capital and transportation costs are also considered. According to the results, the mass flow rate of MSW required is 23.16 Kg/s or 2001 tons/day in dry state and 43.23 Kg/s or 3735 tons/day in wet/moisture state which in actual is easily generated in the Hyderabad city i.e. 4000 tons/day in wet state. The net power output and energy efficiency of the MSW plant are 23.16 Kg/s, 189 MW and 29.93% respectively, which is satisfactory to operate MSW plant. The flue gases including including CO2, SO2, NO are produced at a rate of 41.323, 0.08 and 1.328 Kg/s. Using MSW as fuel source, PKR.6.13 billion can be saved per year.