Abstract— Pempigus encompasses autoimmune bullous conditions, which affect both mucous membranes and the skin. The condition commonly runs a chronic-relapsing cours, with a potentially ruinous on the patient’s quality of life. Pempigus pathogenesis is related to IgG autoantibodies targeting several adhesion molecules in the epidermis, including desmogelin (Dsg) 1 and 3, major elements of desmosomes. Clinical operation of pemphigus is beginning to move down from broad-range immunosuppression and towards B-cell targeted curatives, which reduce numerous cases symptoms but can have significant side effects. Then we’ve review the threat factors regarding pemphigus. The remedies should be specified only when proper diagnosed is done. Both conventional and modernistic methods of recovery remedy have been discussed.